Can particle therapy destroy metastasis?

Nov 21, 2016 Off Comments in Announcement by


A challenging new project has been proposed by TIFPA researchers along with colleagues from Columbia University and Weill Cornell Medical College in New York.The idea is that particle therapy, delivered in high doses to the primary gross tumors, can elicit a strong immune response, and bring cytotoxic T lymphocytes to attack the distal metastasis. Charged particles can be superior to X-rays in causing this immune response, both for biological (cell death pathways) and physical (less damage to naive lymphocytes during the treatment) reasons. Preliminary results and future projects involving the Trento experimental facility at the APSS protontherapy center will be published in the December issue of the official journal of the American Society for Radiation Oncology.

M. Durante, D.J. Brenner and S.C. Formenti, Does heavy ion therapy work through the immune system? Int. J. Radiat. Oncol. Biol. Phys. Vol. 96 n. 5 pp. 934-936, 2016