TIFPA collaborates in large experiments to study matter and forces in space. The Alpha Magnetic Spectrometer (AMS-02) is a detector in operation as an external module of the International Space Station. AMS can detect antimatter in space and found hints of the presence of dark matter. Sophisticated interferometers can detect gravitational waves in space (LISA) and on Earth (VIRGO) and satellite detectors observe particle precipitation from the inner radiation belts to monitor earthquakes on Earth (LIMADOU). The proton beam used at APSS for treating cancer patients is also a tool to simulate space radiation on ground, and will be used to test shielding materials in spacecraft and cosmic radiation damage to microelectronics.